Multistep Resistance Selection and Pae Studies on Antipneumococcal Activity of Lbm415 Compared to Other Agents
نویسندگان
چکیده
Correspondence to: Dr. Peter C. Appelbaum Department of Pathology Hershey Medical Center P.O. Box 850 Hershey, PA 17033 Telephone: (717) 531-5113 Telefax: (717) 531-7953 E-mail: [email protected] AC EP TE D Copyright © 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.01150-06 AAC Accepts, published online ahead of print on 20 November 2006
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Activity of LBM415 compared to those of 11 other agents against Haemophilus species.
When tested against 254 Haemophilus influenzae strains, LBM415, a peptide deformylase inhibitor, gave MIC50 and MIC90 values of 2.0 microg/ml and 8.0 microg/ml, respectively. The MICs were independent of beta-lactam or quinolone susceptibility and the presence or absence of macrolide efflux or ribosomal protein mutations. The MICs of LBM415 against 23 H. parainfluenzae strains were similar to t...
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OBJECTIVES To evaluate the spectrum of activity and potency of LBM415, the first of the peptide deformylase inhibitor (PDFI) class to be developed for treatment of community-acquired respiratory tract infections and uncomplicated skin and soft tissue infections (uSSTI), against a large, contemporary international collection of targeted pathogens collected during 2003-2004. METHODS A total of ...
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